O’Brien is a documentary artist, photographer, and filmmaker and an Assistant Professor of Film and Media Studies at the University of Tulsa. Her work includes a variety of photographic processes, photobooks, independent documentaries, experimental films, audiovisual installations, and archival research. Her photographic, moving image, and multimedia works have been featured in galleries, film festivals, and museums worldwide. She is currently working on an experimental documentary about scratch tickets and producing a photobook series. She holds an M.F.A. in Experimental and Documentary Arts from Duke University.